Your CPU (Processor)
Have you decided on the type of CPU you'll be installing in your new computer? I highly recommend that you select your processor/CPU before selecting your motherboard. If you haven't yet selected your CPU, then visit here first!.

The Chipset and other Integrated Components
When you choose your mainboard, you're also choosing a particular chipset that goes along with it. Your chipset will determine what components will be included along with your motherboard. If you're a light-duty computer user (no high performance games,etc), the a chipset providing onbaord sound, video, ethernet, etc would probably suit your needs. If you're building a serious gaming system, then most onbaord graphics controllers aren't going to meet your expectations. You'll need to step up to a higher performance video card. Your mainboard's onboard components will generally save you money and expansion slot space. For the vast majority of computer users, the onboard audio on most boards is more than adequate. Check to ensure there is an adequate number of USB ports available. Look for at least two-four ports on the rear connector panel and onboard connectors for front-panel USB connections. Look for at least one PCI Express (PCI-E) slot for a video card. If you're purchasing a new hard drive for your computer, go with SATA and ensure that the mainboard supports it.